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dc.contributor.authorNantz, Meri P
dc.contributor.authorRowe, Cheryl A
dc.contributor.authorMuller, Catherine
dc.contributor.authorCreasy, Rebecca
dc.contributor.authorColee, James
dc.contributor.authorKhoo, Christina
dc.contributor.authorPercival, Susan S
dc.date.accessioned2014-01-28T14:24:50Z
dc.date.available2014-01-28T14:24:50Z
dc.date.issued2013-12-13
dc.identifier.citationNutrition Journal. 2013 Dec 13;12(1):161
dc.identifier.urihttp://dx.doi.org/10.1186/1475-2891-12-161
dc.identifier.urihttp://hdl.handle.net/10724/20002
dc.description.abstractAbstract Background Our main objective was to evaluate the ability of cranberry phytochemicals to modify immunity, specifically γδ-T cell proliferation, after daily consumption of a cranberry beverage, and its effect on health outcomes related to cold and influenza symptoms. Methods The study was a randomized, double-blind, placebo-controlled, parallel intervention. Subjects drank a low calorie cranberry beverage (450 ml) made with a juice-derived, powdered cranberry fraction (n = 22) or a placebo beverage (n = 23), daily, for 10 wk. PBMC were cultured for six days with autologous serum and PHA-L stimulation. Cold and influenza symptoms were self-reported. Results The proliferation index of γδ-T cells in culture was almost five times higher after 10 wk of cranberry beverage consumption (p <0.001). In the cranberry beverage group, the incidence of illness was not reduced, however significantly fewer symptoms of illness were reported (p = 0.031). Conclusions Consumption of the cranberry beverage modified the ex vivo proliferation of γδ-T cells. As these cells are located in the epithelium and serve as a first line of defense, improving their function may be related to reducing the number of symptoms associated with a cold and flu. Trial registration ClinicalTrials.gov Identifier: NCT01398150.
dc.titleConsumption of cranberry polyphenols enhances human ¿¿-T cell proliferation and reduces the number of symptoms associated with colds and influenza: a randomized, placebo-controlled intervention study
dc.typeJournal Article
dc.date.updated2013-12-23T12:31:33Z
dc.description.versionPeer Reviewed
dc.language.rfc3066en
dc.rights.holderMeri P Nantz et al.; licensee BioMed Central Ltd.


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