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dc.contributor.authorAlosco, Michael L
dc.contributor.authorBrickman, Adam M
dc.contributor.authorSpitznagel, Mary B
dc.contributor.authorGriffith, Erica Y
dc.contributor.authorNarkhede, Atul
dc.contributor.authorCohen, Ronald
dc.contributor.authorSweet, Lawrence H
dc.contributor.authorHughes, Joel
dc.contributor.authorRosneck, Jim
dc.contributor.authorGunstad, John
dc.date.accessioned2013-11-19T15:53:13Z
dc.date.available2013-11-19T15:53:13Z
dc.date.issued2013-10-30
dc.identifier.citationBehavioral and Brain Functions. 2013 Oct 30;9(1):42
dc.identifier.urihttp://dx.doi.org/10.1186/1744-9081-9-42
dc.identifier.urihttp://hdl.handle.net/10724/19928
dc.description.abstractAbstract Background Poor sleep is common in heart failure (HF), though mechanisms of sleep difficulties are not well understood. Adverse brain changes among regions important for sleep have been demonstrated in patients with HF. Cerebral hypoperfusion, a correlate of sleep quality, is also prevalent in HF and a likely contributor to white matter hyperintensities (WMH). However, no study to date has examined the effects of cerebral blood flow, WMH, and brain volume on sleep quality in HF. Methods Fifty-three HF patients completed the Pittsburgh Sleep Quality Index and underwent brain magnetic resonance imaging to quantify brain and WMH volume. Transcranial Doppler ultrasonography assessed cerebral blood flow velocity of the middle cerebral artery (CBF-V of the MCA). Results 75.5% of HF patients reported impaired sleep. Regression analyses adjusting for medical and demographic factors showed decreased CBF-V of the MCA and greater WMH volume were associated with poor sleep quality. No such pattern emerged on total brain or regional volume indices. Conclusions Decreased cerebral perfusion and greater WMH may contribute to sleep difficulties in HF. Future studies are needed to confirm these findings and clarify the effects of cerebral blood flow and WMH on sleep in healthy and patient samples.
dc.titleReduced cerebral blood flow and white matter hyperintensities predict poor sleep in heart failure
dc.typeJournal Article
dc.date.updated2013-11-04T12:12:26Z
dc.description.versionPeer Reviewed
dc.language.rfc3066en
dc.rights.holderMichael L Alosco et al.; licensee BioMed Central Ltd.


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