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dc.contributor.authorLaing, Roz
dc.contributor.authorKikuchi, Taisei
dc.contributor.authorMartinelli, Axel
dc.contributor.authorTsai, Isheng J
dc.contributor.authorBeech, Robin N
dc.contributor.authorRedman, Elizabeth
dc.contributor.authorHolroyd, Nancy
dc.contributor.authorBartley, David J
dc.contributor.authorBeasley, Helen
dc.contributor.authorBritton, Collette
dc.contributor.authorCurran, David
dc.contributor.authorDevaney, Eileen
dc.contributor.authorGilabert, Aude
dc.contributor.authorHunt, Martin
dc.contributor.authorJackson, Frank
dc.contributor.authorJohnston, Stephanie L
dc.contributor.authorKryukov, Ivan
dc.contributor.authorLi, Keyu
dc.contributor.authorMorrison, Alison A
dc.contributor.authorReid, Adam J
dc.contributor.authorSargison, Neil
dc.contributor.authorSaunders, Gary I
dc.contributor.authorWasmuth, James D
dc.contributor.authorWolstenholme, Adrian
dc.contributor.authorBerriman, Matthew
dc.contributor.authorGilleard, John S
dc.contributor.authorCotton, James A
dc.date.accessioned2013-10-22T12:14:28Z
dc.date.available2013-10-22T12:14:28Z
dc.date.issued2013-08-28
dc.identifier.citationGenome Biology. 2013 Aug 28;14(8):R88
dc.identifier.urihttp://dx.doi.org/10.1186/gb-2013-14-8-r88
dc.identifier.urihttp://hdl.handle.net/10724/19907
dc.description.abstractAbstract Background The small ruminant parasite Haemonchus contortus is the most widely used parasitic nematode in drug discovery, vaccine development and anthelmintic resistance research. Its remarkable propensity to develop resistance threatens the viability of the sheep industry in many regions of the world and provides a cautionary example of the effect of mass drug administration to control parasitic nematodes. Its phylogenetic position makes it particularly well placed for comparison with the free-living nematode Caenorhabditis elegans and the most economically important parasites of livestock and humans. Results Here we report the detailed analysis of a draft genome assembly and extensive transcriptomic dataset for H. contortus. This represents the first genome to be published for a strongylid nematode and the most extensive transcriptomic dataset for any parasitic nematode reported to date. We show a general pattern of conservation of genome structure and gene content between H. contortus and C. elegans, but also a dramatic expansion of important parasite gene families. We identify genes involved in parasite-specific pathways such as blood feeding, neurological function, and drug metabolism. In particular, we describe complete gene repertoires for known drug target families, providing the most comprehensive understanding yet of the action of several important anthelmintics. Also, we identify a set of genes enriched in the parasitic stages of the lifecycle and the parasite gut that provide a rich source of vaccine and drug target candidates. Conclusions The H. contortus genome and transcriptome provide an essential platform for postgenomic research in this and other important strongylid parasites.
dc.titleThe genome and transcriptome of Haemonchus contortus, a key model parasite for drug and vaccine discovery
dc.typeJournal Article
dc.date.updated2013-10-18T11:06:13Z
dc.description.versionPeer Reviewed
dc.language.rfc3066en
dc.rights.holderRoz Laing et al.; licensee BioMed Central Ltd.


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