Show simple item record

dc.contributor.authorMenendez, Laura
dc.contributor.authorBenigno, Benedict B
dc.contributor.authorMcDonald, John F
dc.date.accessioned2013-06-12T15:27:06Z
dc.date.available2013-06-12T15:27:06Z
dc.date.issued2004-04-26
dc.identifier.citationMolecular Cancer. 2004 Apr 26;3(1):12
dc.identifier.urihttp://dx.doi.org/10.1186/1476-4598-3-12
dc.identifier.urihttp://hdl.handle.net/10724/19816
dc.description.abstractAbstract Wide-spread hypomethylation of CpG dinucleotides is characteristic of many cancers. Retrotransposons have been identified as potential targets of hypomethylation during cellular transformation. We report the results of an preliminary examination of the methylation status of CpG dinucleotides associated with the L1 and HERV-W retrotransposons in benign and malignant human ovarian tumors. We find a reduction in the methylation of CpG dinucleotides within the promoter regions of these retroelements in malignant relative to non-malignant ovarian tissues. Consistent with these results, we find that relative L1 and HERV-W expression levels are elevated in representative samples of malignant vs. non-malignant ovarian tissues.
dc.titleL1 and HERV-W retrotransposons are hypomethylated in human ovarian carcinomas
dc.typeJournal Article
dc.date.updated2013-06-07T19:56:25Z
dc.description.versionPeer Reviewed
dc.language.rfc3066en
dc.rights.holderLaura Menendez et al.; licensee BioMed Central Ltd.


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record