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dc.contributor.authorJohansen, Jeanette S
dc.contributor.authorHarris, Alex K
dc.contributor.authorRychly, David J
dc.contributor.authorErgul, Adviye
dc.date.accessioned2013-06-12T15:25:51Z
dc.date.available2013-06-12T15:25:51Z
dc.date.issued2005-04-29
dc.identifier.citationCardiovascular Diabetology. 2005 Apr 29;4(1):5
dc.identifier.urihttp://dx.doi.org/10.1186/1475-2840-4-5
dc.identifier.urihttp://hdl.handle.net/10724/19809
dc.description.abstractAbstract Cardiovascular complications, characterized by endothelial dysfunction and accelerated atherosclerosis, are the leading cause of morbidity and mortality associated with diabetes. There is growing evidence that excess generation of highly reactive free radicals, largely due to hyperglycemia, causes oxidative stress, which further exacerbates the development and progression of diabetes and its complications. Overproduction and/or insufficient removal of these free radicals result in vascular dysfunction, damage to cellular proteins, membrane lipids and nucleic acids. Despite overwhelming evidence on the damaging consequences of oxidative stress and its role in experimental diabetes, large scale clinical trials with classic antioxidants failed to demonstrate any benefit for diabetic patients. As our understanding of the mechanisms of free radical generation evolves, it is becoming clear that rather than merely scavenging reactive radicals, a more comprehensive approach aimed at preventing the generation of these reactive species as well as scavenging may prove more beneficial. Therefore, new strategies with classic as well as new antioxidants should be implemented in the treatment of diabetes.
dc.titleOxidative stress and the use of antioxidants in diabetes: Linking basic science to clinical practice
dc.typeJournal Article
dc.date.updated2013-06-07T19:52:39Z
dc.description.versionPeer Reviewed
dc.language.rfc3066en
dc.rights.holderJeanette Johansen et al.; licensee BioMed Central Ltd.


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