Show simple item record

dc.contributor.authorCondit, Celeste M
dc.contributor.authorRailsback, L Bruce
dc.date.accessioned2013-06-12T15:19:26Z
dc.date.available2013-06-12T15:19:26Z
dc.date.issued2007-10-03
dc.identifier.citationJournal of Biomedical Discovery and Collaboration. 2007 Oct 03;2(1):5
dc.identifier.urihttp://dx.doi.org/10.1186/1747-5333-2-5
dc.identifier.urihttp://hdl.handle.net/10724/19770
dc.description.abstractAbstract Background Biological organisms and their components are better conceived within categories based on similarity rather than on identity. Biologists routinely operate with similarity-based concepts such as "model organism" and "motif." There has been little exploration of the characteristics of the similarity-based categories that exist in biology. This study uses the case of the discovery and classification of zinc finger proteins to explore how biological categories based in similarity are represented. Results The existence of a category of "zinc finger proteins" was based in 1) a lumpy gradient of similarity, 2) a link between function and structure, 3) establishment of a range of appearance across systems and organisms, and 4) an evolutionary locus as a historically based common-ground. Conclusion More systematic application of the idea of similarity-based categorization might eliminate the assumption that biological characteristics can only contribute to narrow categorization of humans. It also raises possibilities for refining data-driven exploration efforts.
dc.titleGeneralization through similarity: motif discourse in the discovery and elaboration of zinc finger proteins
dc.typeJournal Article
dc.date.updated2013-06-07T19:07:25Z
dc.description.versionPeer Reviewed
dc.language.rfc3066en
dc.rights.holderCeleste Condit et al.; licensee BioMed Central Ltd.


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record