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dc.contributor.authorLoftis, Amanda D
dc.contributor.authorMixson, Tonya R
dc.contributor.authorStromdahl, Ellen Y
dc.contributor.authorYabsley, Michael J
dc.contributor.authorGarrison, Laurel E
dc.contributor.authorWilliamson, Phillip C
dc.contributor.authorFitak, Robert R
dc.contributor.authorFuerst, Paul A
dc.contributor.authorKelly, Daryl J
dc.contributor.authorBlount, Keith W
dc.date.accessioned2013-06-12T15:14:26Z
dc.date.available2013-06-12T15:14:26Z
dc.date.issued2008-04-23
dc.identifier.citationBMC Infectious Diseases. 2008 Apr 23;8(1):54
dc.identifier.urihttp://dx.doi.org/10.1186/1471-2334-8-54
dc.identifier.urihttp://hdl.handle.net/10724/19743
dc.description.abstractAbstract Background A novel Ehrlichia, closely related to Ehrlichia ruminantium, was recently discovered from Panola Mountain State Park, GA, USA. We conducted a study to determine if this agent was recently introduced into the United States. Methods We developed a sensitive PCR assay based on the conserved gltA (citrate synthase) gene and tested DNA samples extracted from 1964 field-collected and 1835 human-biting Amblyomma americanum from 23 eastern states of the USA. Results The novel agent was detected in 36 ticks collected from 10 states between 1998 and 2006. Infected ticks were collected both from vegetation (n = 14, 0.7%) and from humans (n = 22, 1.2%). Fragments of the conserved gltA gene and the variable map1 gene were sequenced from positive samples. Two distinct clades, with 10.5% nucleic acid divergence over the 730 bp map1 sequence, were identified. Conclusion These data suggest that the Panola Mountain Ehrlichia was not recently introduced to the United States; this agent has an extensive distribution throughout the range of its tick vector, has been present in some locations for several years, and displays genetic variability. Furthermore, people in several states were exposed to this agent through the bite of infected ticks, underscoring the potential public health risk of this emerging ehrlichiosis.
dc.titleGeographic distribution and genetic diversity of the Ehrlichia sp. from Panola Mountain in Amblyomma americanum
dc.typeJournal Article
dc.date.updated2013-06-07T18:48:51Z
dc.description.versionPeer Reviewed
dc.language.rfc3066en
dc.rights.holderAmanda D Loftis et al.; licensee BioMed Central Ltd.


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