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dc.contributor.authorMao, Xizeng
dc.contributor.authorOlman, Victor
dc.contributor.authorStuart, Rhona
dc.contributor.authorPaulsen, Ian T
dc.contributor.authorPalenik, Brian
dc.contributor.authorXu, Ying
dc.date.accessioned2013-06-12T15:05:39Z
dc.date.available2013-06-12T15:05:39Z
dc.date.issued2010-05-10
dc.identifier.citationBMC Genomics. 2010 May 10;11(1):291
dc.identifier.urihttp://dx.doi.org/10.1186/1471-2164-11-291
dc.identifier.urihttp://hdl.handle.net/10724/19687
dc.description.abstractAbstract Background Osmotic stress is caused by sudden changes in the impermeable solute concentration around a cell, which induces instantaneous water flow in or out of the cell to balance the concentration. Very little is known about the detailed response mechanism to osmotic stress in marine Synechococcus, one of the major oxygenic phototrophic cyanobacterial genera that contribute greatly to the global CO2 fixation. Results We present here a computational study of the osmoregulation network in response to hyperosmotic stress of Synechococcus sp strain WH8102 using comparative genome analyses and computational prediction. In this study, we identified the key transporters, synthetases, signal sensor proteins and transcriptional regulator proteins, and found experimentally that of these proteins, 15 genes showed significantly changed expression levels under a mild hyperosmotic stress. Conclusions From the predicted network model, we have made a number of interesting observations about WH8102. Specifically, we found that (i) the organism likely uses glycine betaine as the major osmolyte, and others such as glucosylglycerol, glucosylglycerate, trehalose, sucrose and arginine as the minor osmolytes, making it efficient and adaptable to its changing environment; and (ii) σ38, one of the seven types of σ factors, probably serves as a global regulator coordinating the osmoregulation network and the other relevant networks.
dc.titleComputational prediction of the osmoregulation network in Synechococcus sp. WH8102
dc.typeJournal Article
dc.date.updated2013-06-07T17:18:00Z
dc.description.versionPeer Reviewed
dc.language.rfc3066en
dc.rights.holderXizeng Mao et al.; licensee BioMed Central Ltd.


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