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dc.contributor.authorCheng, Weixia
dc.contributor.authorChen, Jinan
dc.contributor.authorXu, Ziqian
dc.contributor.authorYu, Jiemei
dc.contributor.authorHuang, Canping
dc.contributor.authorJin, Miao
dc.contributor.authorLi, Huiying
dc.contributor.authorZhang, Ming
dc.contributor.authorJin, Yu
dc.contributor.authorDuan, Zhao-jun
dc.date.accessioned2013-06-12T15:01:14Z
dc.date.available2013-06-12T15:01:14Z
dc.date.issued2011-02-24
dc.identifier.citationBMC Infectious Diseases. 2011 Feb 24;11(1):50
dc.identifier.urihttp://dx.doi.org/10.1186/1471-2334-11-50
dc.identifier.urihttp://hdl.handle.net/10724/19650
dc.description.abstractAbstract Background Human bocavirus 2(HBoV2) and other human bocavirus species (HBoV, HBoV3, and HBoV4) have been discovered recently. But the precise phylogenetic relationships among these viruses are not clear yet. Methods We collected 632 diarrhea and 162 healthy children in Lanzhou, China. Using PCR, Human bocavirus (HBoV), HBoV2, HBoV3 and HBoV4 were screened. The partial genes of NS, NP1 and VP, and two nearly complete sequences of HBoV2 were obtained. Result Phylogenetic analysis showed the different genes of HBoV2 strain were homogenous with different reference strains. HBoV3 may be a recombinant derived from HBoV and HBoV4. We also observed that the VP1 and VP2 region of HBoV3 is as similar to HBoV2 as to HBoV4. Conclusions A single genetic lineage of HBoV2 is circulating in children with and without gastroenteritis in Lanzhou, China. Current evidence in this study was not enough to support recombination between HBoV2 strains, and HBoV3 may be a recombinant between HBoV and the common ancestor of HBoV2 and HBoV4.
dc.titlePhylogenetic and Recombination Analysis of human bocavirus 2
dc.typeJournal Article
dc.date.updated2013-06-07T16:41:15Z
dc.description.versionPeer Reviewed
dc.language.rfc3066en
dc.rights.holderWeixia Cheng et al.; licensee BioMed Central Ltd.


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