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dc.contributor.authorAbel, Jacob
dc.contributor.authorMrázek, Jan
dc.date.accessioned2013-06-12T14:53:07Z
dc.date.available2013-06-12T14:53:07Z
dc.date.issued2012-05-15
dc.identifier.citationBMC Genomics. 2012 May 15;13(1):188
dc.identifier.urihttp://dx.doi.org/10.1186/1471-2164-13-188
dc.identifier.urihttp://hdl.handle.net/10724/19589
dc.description.abstractAbstractBackgroundPeriodic spacing of A-tracts (short runs of A or T) with the DNA helical period of ~10–11 bp is characteristic of intrinsically bent DNA. In eukaryotes, the DNA bending is related to chromatin structure and nucleosome positioning. However, the physiological role of strong sequence periodicity detected in many prokaryotic genomes is not clear.ResultsWe developed measures of intensity and persistency of DNA curvature-related sequence periodicity and applied them to prokaryotic chromosomes and phages. The results indicate that strong periodic signals present in chromosomes are generally absent in phage genomes. Moreover, chromosomes containing prophages are less likely to possess a persistent periodic signal than chromosomes with no prophages.ConclusionsAbsence of DNA curvature-related sequence periodicity in phages could arise from constraints associated with DNA packaging in the viral capsid. Lack of prophages in chromosomes with persistent periodic signal suggests that the sequence periodicity and concomitant DNA curvature could play a role in protecting the chromosomes from integration of phage DNA.
dc.titleDifferences in DNA curvature-related sequence periodicity between prokaryotic chromosomes and phages, and relationship to chromosomal prophage content
dc.typeJournal Article
dc.date.updated2013-06-07T13:44:42Z
dc.description.versionPeer Reviewed
dc.language.rfc3066en
dc.rights.holderJacob Abel et al.; licensee BioMed Central Ltd.


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