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dc.contributor.authorVenn-Watson, Stephanie
dc.contributor.authorBenham, Celeste
dc.contributor.authorGulland, Frances M
dc.contributor.authorSmith, Cynthia R
dc.contributor.authorSt Leger, Judy
dc.contributor.authorYochem, Pam
dc.contributor.authorNollens, Hendrik
dc.contributor.authorBlas-Machado, Uriel
dc.contributor.authorSaliki, Jeremiah
dc.contributor.authorColegrove, Katie
dc.contributor.authorWellehan, James FX Jr
dc.contributor.authorRivera, Rebecca
dc.date.accessioned2013-06-12T14:48:47Z
dc.date.available2013-06-12T14:48:47Z
dc.date.issued2012-12-12
dc.identifier.citationVeterinary Research. 2012 Dec 12;43(1):85
dc.identifier.urihttp://dx.doi.org/10.1186/1297-9716-43-85
dc.identifier.urihttp://hdl.handle.net/10724/19557
dc.description.abstractAbstract Herpesviruses have been recognized in marine mammals, but their clinical relevance is not always easy to assess. A novel otarine herpesvirus-3 (OtHV3) was detected in a geriatric California sea lion (Zalophus californianus), and using a newly developed quantitative PCR assay paired with histology, OtHV3 was associated with esophageal ulcers and B cell lymphoblastic lymphoma in this animal. The prevalence and quantities of OtHV3 were then determined among buffy coats from 87 stranded and managed collection sea lions. Stranded sea lions had a higher prevalence of OtHV3 compared to managed collection sea lions (34.9% versus 12.5%; p = 0.04), and among the stranded sea lions, yearlings were most likely to be positive. Future epidemiological studies comparing the presence and viral loads of OtHV3 among a larger population of California sea lions with and without lymphoid neoplasia or esophageal ulcers would help elucidate the relevance of OtHV3-associated pathologies to these groups.
dc.titleClinical relevance of novel Otarine herpesvirus-3 in California sea lions (Zalophus californianus): lymphoma, esophageal ulcers, and strandings
dc.typeJournal Article
dc.date.updated2013-06-07T13:17:01Z
dc.description.versionPeer Reviewed
dc.language.rfc3066en
dc.rights.holderStephanie Venn-Watson et al.; licensee BioMed Central Ltd.


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