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dc.contributor.authorBauer, Sarah E
dc.contributor.authorWagner, Sara E
dc.contributor.authorBurch, Jim
dc.contributor.authorBayakly, Rana
dc.contributor.authorVena, John E
dc.date.accessioned2013-06-12T14:46:01Z
dc.date.available2013-06-12T14:46:01Z
dc.date.issued2013-04-17
dc.identifier.citationInternational Journal of Health Geographics. 2013 Apr 17;12(1):23
dc.identifier.urihttp://dx.doi.org/10.1186/1476-072X-12-23
dc.identifier.urihttp://hdl.handle.net/10724/19535
dc.description.abstractAbstract Background Literature has identified detrimental health effects from the indiscriminate use of artificial nighttime light. We examined the co-distribution of light at night (LAN) and breast cancer (BC) incidence in Georgia, with the goal to contribute to the accumulating evidence that exposure to LAN increases risk of BC. Methods Using Georgia Comprehensive Cancer Registry data (2000–2007), we conducted a case-referent study among 34,053 BC cases and 14,458 lung cancer referents. Individuals with lung cancer were used as referents to control for other cancer risk factors that may be associated with elevated LAN, such as air pollution, and since this cancer type was not previously associated with LAN or circadian rhythm disruption. DMSP-OLS Nighttime Light Time Series satellite images (1992–2007) were used to estimate LAN levels; low (0–20 watts per sterradian cm2), medium (21–41 watts per sterradian cm2), high (>41 watts per sterradian cm2). LAN levels were extracted for each year of exposure prior to case/referent diagnosis in ArcGIS. Results Odds ratios (OR) and 95% confidence intervals (CI) were estimated using logistic regression models controlling for individual-level year of diagnosis, race, age at diagnosis, tumor grade, stage; and population-level determinants including metropolitan statistical area (MSA) status, births per 1,000 women aged 15–50, percentage of female smokers, MSA population mobility, and percentage of population over 16 in the labor force. We found that overall BC incidence was associated with high LAN exposure (OR = 1.12, 95% CI [1.04, 1.20]). When stratified by race, LAN exposure was associated with increased BC risk among whites (OR = 1.13, 95% CI [1.05, 1.22]), but not among blacks (OR = 1.02, 95% CI [0.82, 1.28]). Conclusions Our results suggest positive associations between LAN and BC incidence, especially among whites. The consistency of our findings with previous studies suggests that there could be fundamental biological links between exposure to artificial LAN and increased BC incidence, although additional research using exposure metrics at the individual level is required to confirm or refute these findings.
dc.titleA case-referent study: light at night and breast cancer risk in Georgia
dc.typeJournal Article
dc.date.updated2013-06-07T12:44:33Z
dc.description.versionPeer Reviewed
dc.language.rfc3066en
dc.rights.holderSarah E Bauer et al.; licensee BioMed Central Ltd.


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