Now showing items 1-10 of 903
Targeting melanoma growth and viability reveals dualistic functionality of the phosphonothionate analogue of carba cyclic phosphatidic acid
Abstract Background Although the incidence of melanoma in the U.S. is rising faster than any other cancer, the FDA-approved chemotherapies lack efficacy for advanced disease, which results in poor overall survival. ...
Advancing Data Reuse in Phyloinformatics Using an Ontology-Driven Semantic Web Approach
Abstract Phylogenetic analyses can resolve historical relationships among genes, organisms or higher taxa. Understanding such relationships can elucidate a wide range of biological phenomena, ...
AntEpiSeeker: detecting epistatic interactions for case-control studies using a two-stage ant colony optimization algorithm
Abstract Background Epistatic interactions of multiple single nucleotide polymorphisms (SNPs) are now believed to affect individual ...
Open questions: genomics and how far we haven¿t come
Biosynthesis of caffeic acid in Escherichia coli using its endogenous hydroxylase complex
Abstract Background Caffeic acid (3,4-dihydroxycinnamic acid) is a natural phenolic compound derived from the plant phenylpropanoid pathway. Caffeic acid and its phenethyl ...
Classification of genomic islands using decision trees and their ensemble algorithms
Abstract Background Genomic islands (GIs) are clusters of alien genes in some bacterial genomes, but not be seen in the genomes of ...
Vaccination with attenuated Salmonella enterica Dublin expressing E. coli O157:H7 outer membrane protein Intimin induces transient reduction of fecal shedding of E. coli O157:H7 in cattle
Abstract Background Escherichia coli serogroup O157:H7 has emerged as an important zoonotic bacterial pathogen, causing a range of ...
Spatial-temporal targeting of lung-specific mesenchyme by a Tbx4 enhancer
Abstract Background Reciprocal interactions between lung mesenchymal and epithelial cells play essential roles in lung organogenesis and homeostasis. Although the molecular markers and related ...
Identifying accelerometer nonwear and wear time in older adults
Abstract Background Five accelerometer-derived methods of identifying nonwear and wear time were compared with a self-report criterion in adults ≥ 56 years of ...
Higher BMI is associated with reduced brain volume in heart failure
Abstract Background Heart failure (HF) patients are at risk for structural brain changes due to cerebral hypoperfusion. Past work shows obesity is linked with reduced cerebral blood flow and ...