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Targeting melanoma growth and viability reveals dualistic functionality of the phosphonothionate analogue of carba cyclic phosphatidic acid
(2010-06-09)
Abstract
Background
Although the incidence of melanoma in the U.S. is rising faster than any other cancer, the FDA-approved chemotherapies lack efficacy for advanced disease, which results in poor overall survival. ...
AntEpiSeeker: detecting epistatic interactions for case-control studies using a two-stage ant colony optimization algorithm
(2010-04-28)
Abstract
Background
Epistatic interactions of multiple single nucleotide polymorphisms (SNPs) are now believed to affect individual ...
Classification of genomic islands using decision trees and their ensemble algorithms
(2010-11-02)
Abstract
Background
Genomic islands (GIs) are clusters of alien genes in some bacterial genomes, but not be seen in the genomes of ...
Vaccination with attenuated Salmonella enterica Dublin expressing E. coli O157:H7 outer membrane protein Intimin induces transient reduction of fecal shedding of E. coli O157:H7 in cattle
(2010-07-07)
Abstract
Background
Escherichia coli serogroup O157:H7 has emerged as an important zoonotic bacterial pathogen, causing a range of ...
2K09 and thereafter : the coming era of integrative bioinformatics, systems biology and intelligent computing for functional genomics and personalized medicine research
(2010-12-01)
Abstract
Significant interest exists in establishing synergistic research in bioinformatics, systems biology and intelligent computing. Supported by the United States National Science Foundation ...
Green tea polyphenols supplementation and Tai Chi exercise for postmenopausal osteopenic women: safety and quality of life report
(2010-12-09)
Abstract
Background
Evidence suggests that both green tea polyphenols (GTP) and Tai Chi (TC) exercise may benefit bone health in osteopenic women. However, their safety in this population has never been systematically ...
Associations of quality of life with physical activity, fruit and vegetable consumption, and physical inactivity in a free living, multiethnic population in Hawaii: a longitudinal study
(2010-11-22)
Abstract
Introduction
High intake of fruit and vegetables and being physically active are associated with reduced risk of chronic diseases. In the current study, we examined the associations of physical activity, fruit ...
Neuroprotective effects and mechanism of cognitive-enhancing choline analogs JWB 1-84-1 and JAY 2-22-33 in neuronal culture and Caenorhabditis elegans
(2010-12-16)
Abstract
Background
Our previous work indicated that novel analogs of choline have cytoprotective effects in vitro that might be useful in neurodegenerative conditions such as Alzheimer's disease (AD). Furthermore, two ...
Detection of multiple strains of Mycobacterium tuberculosis using MIRU-VNTR in patients with pulmonary tuberculosis in Kampala, Uganda
(2010-12-10)
Abstract
Background
Many studies using DNA fingerprinting to differentiate Mycobacterium tuberculosis (MTB) strains reveal single strains in cultures, suggesting that most disease is caused by infection with a single strain. ...
Suicide and unintentional poisoning mortality trends in the United States, 1987-2006: Two unrelated phenomena?
(2010-11-17)
Abstract
Background
Two counter trends in injury mortality have been separately reported in the US in recent times - a declining suicide rate and a rapidly rising unintentional poisoning mortality rate. Poisoning ...