Now showing items 1-5 of 5
Delayed minocycline inhibits ischemia-activated matrix metalloproteinases 2 and 9 after experimental stroke
Abstract Background Matrix metalloproteinases 2 and 9 (MMP-2 and MMP-9) are increased in the brain after experimental ischemic stroke in rats. These two proteases are involved with the ...
Oxidative stress and the use of antioxidants in diabetes: Linking basic science to clinical practice
Abstract Cardiovascular complications, characterized by endothelial dysfunction and accelerated atherosclerosis, are the leading cause of morbidity and mortality associated with diabetes. There is ...
Increased hemorrhagic transformation and altered infarct size and localization after experimental stroke in a rat model of type 2 diabetes
Abstract Background Interruption of flow through of cerebral blood vessels results in acute ischemic stroke. Subsequent breakdown ...
Type-2 diabetes-induced changes in vascular extracellular matrix gene expression: Relation to vessel size
Abstract Background Hyperglycemia-induced changes in vascular wall structure contribute to the pathogenesis of diabetic microvascular and macrovascular complications. Matrix metalloproteinases ...
Effect of neutrophil depletion on gelatinase expression, edema formation and hemorrhagic transformation after focal ischemic stroke
Abstract Background While gelatinase (MMP-2 and -9) activity is increased after focal ischemia/reperfusion injury in the brain, the ...