Browsing BioMed Central Open Access Articles by Title
Now showing items 729-748 of 1066
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P-glycoprotein confers acquired resistance to 17-DMAG in lung cancers with an ALK rearrangement
(2015-07-29)Abstract Background Because anaplastic lymphoma kinase (ALK) is dependent on Hsp90 for protein stability, Hsp90 inhibitors are effective in controlling growth of lung cancer ... -
Paclitaxel induces acute pain via directly activating toll like receptor 4
(2015-03-11)Abstract Paclitaxel, a powerful anti-neoplastic drug, often causes pathological pain, which significantly reduces the quality of life in patients. Paclitaxel-induced pain includes pain that occurs immediately ... -
Pain medication use after spine surgery: is it assessed in the literature? A systematic review, January 2000–December 2009
(2015-07-29)Abstract Background Spine surgery is one of the most difficult areas in which to achieve a good clinical outcome and pain medication is often used for a long period of time ... -
Parasite accumulation in placenta of non-immune baboons during Plasmodium knowlesi infection
(2015-03-18)Abstract Background Placental malaria (PM) causes adverse pregnancy outcomes in the mother and her foetus. It is difficult to study PM directly in humans due to ethical ... -
Parasitic wasp responses to symbiont-based defense in aphids
(2012-02-24)Abstract Background Recent findings indicate that several insect lineages receive protection against particular natural enemies through infection with heritable symbionts, but little is yet known about whether enemies ... -
Parental intimate partner homicide and its consequences for children: protocol for a population-based study
(2015-07-29)Abstract Background The loss of a parent due to intimate partner homicide has a major impact on children. Professionals involved have to make far-reaching decisions regarding ... -
Partial inhibition of the ubiquitin–proteasome system ameliorates cardiac dysfunction following ischemia–reperfusion in the presence of high glucose
(2015-07-28)Abstract Background Acute hyperglycemia co-presenting with myocardial infarction (in diabetic and non-diabetic individuals) is often associated with a poor prognosis. Although ... -
Paternal and maternal bonding styles in childhood are associated with the prevalence of chronic pain in a general adult population: the Hisayama Study
(2015-07-31)Abstract Background Previous research has suggested that extraordinary adverse experiences during childhood, such as abuse, are possible risk factors for the development of ... -
Patterns of health-related quality of life and associated factors in Chinese patients undergoing haemodialysis
(2015-07-29)Abstract Background Haemodialysis (HD) is a life-saving but burdensome therapy for patients with end-stage renal disease (ESRD) which can have a detrimental impact on patients’ ... -
Peanut gene expression profiling in developing seeds at different reproduction stages during Aspergillus parasiticus infection
(2008-02-04)Abstract Background Peanut (Arachis hypogaea L.) is an important crop economically and nutritionally, and is one of the most ... -
PEP-1-CAT protects hypoxia/reoxygenation-induced cardiomyocyte apoptosis through multiple sigaling pathways
(2013-05-06)Abstract Background Catalase (CAT) breaks down H2O2 into H2O and O2 to protects cells from oxidative damage. However, its translational potential is limited because exogenous CAT cannot enter ... -
PEP-1-SOD1 fusion proteins block cardiac myofibroblast activation and angiotensin II-induced collagen production
(2015-10-07)Abstract Background Oxidative stress is closely associated with cardiac fibrosis. However, the effect of copper, zinc-superoxide dismutase (SOD1) as a therapeutic agent is ... -
Perceived benefits and health risks of cigarette smoking among young adults: insights from a cross-sectional study
(2015-07-31)Abstract Background Perceptions of smoking-related health risks and benefits among young adults (18–24 years) and their smoking behaviour have not been adequately studied in ... -
Perception of drinking water safety and factors influencing acceptance and sustainability of a water quality intervention in rural southern India
(2015-07-30)Abstract Background Acceptance and long-term sustainability of water quality interventions are pivotal to realizing continued health benefits. However, there is limited research ... -
Periventricular heterotopia and white matter abnormalities in a girl with mosaic ring chromosome 6
(2015-07-26)Abstract Ring chromosome 6 is a rare chromosome abnormality that arises typically de novo. The phenotypes can be highly variable, ranging from almost normal to severe malformations and neurological defects. ... -
PerPlot & PerScan: Tools for analysis of DNA curvature-related periodicity in genomic nucleotide sequences
(2011-11-28)Abstract Background Periodic spacing of short adenine or thymine runs phased with DNA helical period of ~10.5 bp is associated with intrinsic DNA curvature and deformability, which play important roles in DNA-protein ... -
Pharmacokinetic properties and antitumor efficacy of the 5-fluorouracil loaded PEG-hydrogel
(2010-05-18)Abstract Background We have studied the in vitro and in vivo utility of polyethylene glycol (PEG)-hydrogels for the development of ...