Browsing BioMed Central Open Access Articles by Title
Now showing items 607-626 of 1066
-
JAK kinase inhibitors for the treatment of acute lymphoblastic leukemia
(2015-07-26)Abstract Recent studies of acute lymphoblastic leukemia have identified activating mutations in components of the interleukin-7 receptor complex (IL7R, JAK1, and JAK3). It will be of interest to investigate ... -
Joint association between birth weight at term and later life adherence to a healthy lifestyle with risk of hypertension: a prospective cohort study
(2015-07-31)Abstract Background Low birth weight and unhealthy lifestyles in adulthood have been independently associated with an elevated risk of hypertension. However, no study has ... -
KCNQ channels in nociceptive cold-sensing trigeminal ganglion neurons as therapeutic targets for treating orofacial cold hyperalgesia
(2015-07-31)Abstract Background Hyperexcitability of nociceptive afferent fibers is an underlying mechanism of neuropathic pain and ion channels involved in neuronal excitability are ... -
Kinetic discrimination of self/non-self RNA by the ATPase activity of RIG-I and MDA5
(2015-07-28)Abstract Background The cytoplasmic RIG-like receptors are responsible for the early detection of viruses and other intracellular microbes by activating the innate immune ... -
Knowledge and attitudes towards use of long acting reversible contraceptives among women of reproductive age in Lubaga division, Kampala district, Uganda
(2014-03-17)Abstract Background Uganda has one of the highest total fertility rates globally and in Sub-Saharan Africa. Her high fertility is mainly attributed to the high unmet need for family planning. ... -
Knowledge, attitudes and practices of malaria in Colombia
(2014-05-01)Abstract Background Although Colombia has witnessed an important decrease in malaria transmission, the disease remains a public health problem with an estimated ~10 million people currently ... -
Krüppel-like factor 12 is a novel negative regulator of forkhead box O1 expression: a potential role in impaired decidualization
(2015-07-30)Abstract Background Decidualization is a prerequisite for successful implantation and the establishment of pregnancy. Krüppel-like factor 12 (KLF12) is a negative regulator ... -
L1 and HERV-W retrotransposons are hypomethylated in human ovarian carcinomas
(2004-04-26)Abstract Wide-spread hypomethylation of CpG dinucleotides is characteristic of many cancers. Retrotransposons have been identified as potential targets of hypomethylation during cellular transformation. ... -
Laparoscopic versus open gastrectomy for gastric cancer, a multicenter prospectively randomized controlled trial (LOGICA-trial)
(2015-07-29)Abstract Background For gastric cancer patients, surgical resection with en-bloc lymphadenectomy is the cornerstone of curative treatment. Open gastrectomy has long been the ... -
Larval midgut modifications associated with Bti resistance in the yellow fever mosquito using proteomic and transcriptomic approaches
(2012-06-15)AbstractBackgroundBacillus thuringiensis var. israelensis (Bti) is a natural larval mosquito pathogen producing pore-forming toxins targeting the midgut of Diptera larvae. It is used worldwide for mosquito control. Resistance ... -
Lectin binding profiles of SSEA-4 enriched, pluripotent human embryonic stem cell surfaces
(2005-07-21)Abstract Background Pluripotent human embryonic stem cells (hESCs) have the potential to form every cell type in the body. These ... -
LED-Induced fluorescence and image analysis to detect stink bug damage in cotton bolls
(2013-02-20)Abstract Background Stink bugs represent a major agricultural pest complex attacking more than 200 wild and cultivated plants, including cotton in the southeastern US. Stink bug feeding on ... -
Leishmaniasis sand fly vector density reduction is less marked in destitute housing after insecticide thermal fogging
(2013-06-06)Abstract Background Insecticide thermal fogging (ITF) is a tool to control vector borne diseases. Insecticide application success for vector control has been associated with housing materials and ... -
Leukocyte presence does not increase microbicidal activity of Platelet-rich Plasma in vitro
(2015-07-30)Abstract Background Human platelets are a rich reservoir of molecules that promote regenerative processes and microbicidal activity. This activity might be increased by ... -
Lifetime risk of being diagnosed with, or dying from, prostate cancer by major ethnic group in England 2008–2010
(2015-07-30)Abstract Background In the UK, a man’s lifetime risk of being diagnosed with prostate cancer is 1 in 8. We calculated both the lifetime risk of being diagnosed with and dying ... -
Limitations of three-dimensional power Doppler angiography in preoperative evaluation of ovarian tumors
(2015-07-29)Abstract Background This study describes the accuracy of three-dimensional power Doppler (3D-PD) angiography as secondary method for differential diagnosis of ovarian tumors. ... -
Linking vitamin B1 with cancer cell metabolism
(2013-07-24)Abstract The resurgence of interest in cancer metabolism has linked alterations in the regulation and exploitation of metabolic pathways with an anabolic phenotype that increases biomass production for the replication ... -
Lipoprotein heterogeneity in persons with Spinal Cord Injury: a model of prolonged sitting and restricted physical activity
(2015-07-28)Abstract Background Persons with spinal cord injury (SCI) often have low levels of physical activity, which predispose to increased adiposity and decreased high density ... -
Lobular breast cancer - the most common special subtype or a most special common subtype?
(2015-07-28)Abstract Lobular breast cancer is not only the second most common breast cancer subtype, known for decades, but also a tumour entity that still poses many unresolved questions. These include questions about ... -
Logarithmic gap costs decrease alignment accuracy
(2006-12-05)Abstract Background Studies on the distribution of indel sizes have consistently found that they obey a power law. This finding has lead several scientists to propose that logarithmic gap ...