Reduced cerebral blood flow and white matter hyperintensities predict poor sleep in heart failure

DSpace/Manakin Repository

Reduced cerebral blood flow and white matter hyperintensities predict poor sleep in heart failure

Show full item record

Title: Reduced cerebral blood flow and white matter hyperintensities predict poor sleep in heart failure
Author: Alosco, Michael L; Brickman, Adam M; Spitznagel, Mary B; Griffith, Erica Y; Narkhede, Atul; Cohen, Ronald; Sweet, Lawrence H; Hughes, Joel; Rosneck, Jim; Gunstad, John
Abstract: Abstract Background Poor sleep is common in heart failure (HF), though mechanisms of sleep difficulties are not well understood. Adverse brain changes among regions important for sleep have been demonstrated in patients with HF. Cerebral hypoperfusion, a correlate of sleep quality, is also prevalent in HF and a likely contributor to white matter hyperintensities (WMH). However, no study to date has examined the effects of cerebral blood flow, WMH, and brain volume on sleep quality in HF. Methods Fifty-three HF patients completed the Pittsburgh Sleep Quality Index and underwent brain magnetic resonance imaging to quantify brain and WMH volume. Transcranial Doppler ultrasonography assessed cerebral blood flow velocity of the middle cerebral artery (CBF-V of the MCA). Results 75.5% of HF patients reported impaired sleep. Regression analyses adjusting for medical and demographic factors showed decreased CBF-V of the MCA and greater WMH volume were associated with poor sleep quality. No such pattern emerged on total brain or regional volume indices. Conclusions Decreased cerebral perfusion and greater WMH may contribute to sleep difficulties in HF. Future studies are needed to confirm these findings and clarify the effects of cerebral blood flow and WMH on sleep in healthy and patient samples.
URI: http://dx.doi.org/10.1186/1744-9081-9-42
http://hdl.handle.net/10724/33379
Date: 2013-10-30


Files in this item

Files Size Format View
12993_2013_Article_474.pdf 329.0Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record

Search Athenaeum


Browse

My Account